New 4150 style Sniper EFI

If you care about reliability, I'm not sure that aftermarket EFI with the ECU mounted above the manifold would be the solution in the long run [start researching the failure rates of long-term units].

As long as you understand these systems share no relation in durability to your modern daily driver [Holley, FiTech, or Edelbrock has zero liability unlike an auto manufacture] - then you're headed in the right direction. Timing control will net you better fuel economy, typically there is little change other than that, fuel curve swings a bit more wildly with your carburetor - but it makes little difference in power / MPG figures.