This is why making broad generalizations is a bad thing.
How much power do you lose running a 100 PSI system? Answer: it depends. Sometimes it makes power.
Just like the old LIE that a mag takes a bunch of power to run. They take less than 1 horsepower. Less than 1, yet all the whiz bangs in gym shorts and guru internet stooges who've never seen a mag let alone used on will claim you are losing power running a mag.
The FACT is it is combination dependent. If all you build is 6500 RPM stuff than most things don't matter.
When you try to build power and RPM its two different worlds.