Dual quads versus big hammer!!!...

lean or rich.... ok, that wouldn't be my concern. IF those flaps don't come open, your in trouble. And, as you have discovered, TQ's and the such with a back flap cannot be set in the garage idling in neutral. Trust me, for years TQ's were the carb of my choice and all I ran. Tuning them to 340's, 360s, and even 318's in heavy trucks with tight converters, and no bog. Going lean on the primaries could be "offsetting" for the back flaps not opening. It runs better, but not the solution to your problem. I cannot believe a 625 Demon out of the box that was designed for a stock 350 Camaro is too fat for that 410 C.I. with headers and ported heads. I'm not there, but I think it's deeper than leaning out your primaries.
If you look at the carbs reviews and even the tuning kit reviews everybody and I mean everybody is saying they are way too rich out of the box.. nowhere have I found or somebody said they had to put richer or larger jet's in them.. times that by 2 and I may have a extremely rich situation...