Safe to use Wheel Adapters 5 on 4" to 4.5"?

What's that you were saying? Not a different pattern? Not a separate set of studs?

2014 Dodge 3500 Ram 3500 Dually Adapters M14x1.5 | eBay
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Dodge 3500 2000-2011 2000-2011 DODGE RAM 3500 DUALLY FRONT WHEEL ADAPTERS | eBay
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It doesn't matter. As long as there's enough metal around the studs, it's perfectly safe. Yes, adding an additional set of lug nuts does complicate things, you do need to make sure ALL of the lug nuts are properly torqued and checked periodically. But if you do that, they're perfectly safe. If you look at the wheels you're bolting on, and consider the thickness that they have and their construction, the wheel is usually the weakest link.

Those are entirely different than what we're talking about here.

That said, I said in my first post that "I" personally would not use wheel spacers or adapters of any kind. You marked disagree, but you cannot disagree with what I will do on MY stuff, because it's mine, not yours.