small block heads for a long distance cruiser

The trans is a wide ratio, so 1st will be like 4.30s with a torqueflite 727 and 4th will be like 2.80s with a 727 (in third). tires are R245 -60-1
Hang on; you said;
"so 1st will be like 4.30s with a torqueflite 727"
This points to (2.45x4.30)/2.74=3.84s in the back.
And you said;
"4th will be like 2.80s with a 727 (in third)"
This points to 2.80/.69=4.06s in the back.
So my take-away is that this is NOT a Mopar overdrive trans.
No big deal.

For a Long-distance cruiser, with a
2.80 final-drive ratio, and
245/60-14s;(~25.5 tall) your cruise speed of
65mph equates to 2400 rpm. And 75=2770
Let say that trans has a .67 od then your rear gear is ~4.18 rounds to 4.10s
So; what's the deal?
Are you striving for fuel economy? Then get a 273/318
the 340 is out unless you consider a special build.Cuz the 340 cam sucks gas big-time. Run a smaller cam and it could be back on the table.
If you are gonna run a 270* type cam, it's gonna be hard on fuel no matter what brand you buy, so the 360 is the one you want. The longer stroke will give you a fighting chance to pull some mpg numbers.
This;
so 1st will be like 4.30s with a torqueflite; speaks to say; 3.91s in the back and a starter gear of 10.04, so really, you could run right on down to a 318 or smaller engine depending on your power Requirement.

But if power is a factor, just go straight the 360. I mean they are relatively cheap and easy to build. But with a 10/1 starter gear yur gonna annihilate a lotta 245s