One thing leads to another... mean 318?

When It comes to power there really no reason not do the 318, it can take all the same parts as its to bigger siblings, the slightly smaller bores will have some effect, after an over boring it's really not that far off from a 4 bore.
With same cranks theres only like 20 cid difference give or take between them. Even at stock displacement, theres tons of strong 5.0l out there.

It all comes down to your requirements and level of compromises, If you build an engine to X power and stall and gear it etc.. to best performance and driveablity is a distance thought then it don't matter what size you build, but if you tied to a certain gear ratio eg. 2.76, 2.94, 3.23, 3.55 etc.. Higher gears are gonna be closer optimised to larger displacement, and larger displacements will allow you to get away with larger cams "more power' for any given gear ratio. Which is no problem for some cause they don't care about max performance for a given gear ratio and HP level, and more about building a decent so called under dog /6, 273, 318.

If your willing to gear it build it if not build a larger displacement.
Or take solace in your compromises.