Quarter window roller replacement questions

Do the regulators have to come out to change the rollers or is there a way to get some slack to change the rollers out one at a time?

On my 69 there wasn't much room to work. Mark all the adjustment locations with a sharpie and take it out. This gives you a chance to go through it all and make sure everything is legit. Do one side at a time so you can reference the other side.