Cams choice, Low CR vs VE%

Read a few Dozens threads over the years and a couple recently about Cam choice with low CR engines.

Not saying CR ain't important but most are stuck with what they got for one reason or another.
There's always a few who get super concerned about adding any cam not to lose any more dynamic CR and scare the OP's from doing anything. My feeling is that adding duration to low CR ain't ideal but it's better than stock low powered engine. eg adding cam and even 360 heads to a stock 318 short block with little concern for it's final CR or dynamic CR, worked for me a few times and others I know and people on here. Not recommending that especially now that we have magnum and other high flowing closed chambered heads.

What I am wondering is adding cam and even head flow while sacrificing compression, does it work sometimes, cause even though there's less cr but probably have more VE%? so there's more air to compress, people leaving out VE% when factoring dynamic CR?