Cams choice, Low CR vs VE%

I'm not talking about putting a like an 285 in a low cr 318 or something like that or scavenging per say. But adding mild to slightly over cammed. Idle to 4500 - 5000.

What I'm trying to figure out, does added air flow "VE%" from bigger cam offset the lower dynamic cr.

If 318 stock say is 80-85% VE so would act more like 250-290 cid if cam adds 5-10% VE thats like 15-30 cid of air.
So if dynamic CR drops 5-10% wouldn't that possibly just even out or ?
The intake charge is being compressed less but there more air to compress.