Cams choice, Low CR vs VE%

I'm not talking about putting a like an 285 in a low cr 318 or something like that or scavenging per say. But adding mild to slightly over cammed. Idle to 4500 - 5000.

What I'm trying to figure out, does added air flow "VE%" from bigger cam offset the lower dynamic cr.

If 318 stock say is 80-85% VE so would act more like 250-290 cid if cam adds 5-10% VE thats like 15-30 cid of air.
So if dynamic CR drops 5-10% wouldn't that possibly just even out or ?
The intake charge is being compressed less but there more air to compress.
Only if the intake closing event happens later. Some cams with more duration can Infact have an earlier closing than say a smaller one. Which would bring up dcr.. interesting thread. I wish I had an engine dyno to do unlimited tests in.