Holley stumble trouble

I’ve tried initial timing settings all the way from 10* to 22* and everywhere in between while recurving the distributor to achieve settings of 30* to 38* total.
The stumble seems to occur just as I start to give it a little more throttle during cruise. I have a vacuum gauge in the car and the stumble occurs at about 14” which is just about where steady cruise vacuum is -15”.
I guess I dont understand why you have this issue with that much vacuum?
I only had stumble issue with engine that had half the vacuum you have.