Incorrect Timing Adjustment causing heat issues?

I brought me 67 273 2bbl from CA to northern CO. (5000 feet). I assumed the same and rejected my carb. Ran like crap. Misfiring etc.

Discovered the 2 steps lean was causing lean misfire. I put the OEM jets back in and no more issue. Turns out 5000 feet is not that high.
Did you try just one step lean?