Karting??..

Changing the spindle height will change the weight in a diagonal fashion. Changing the wheel locations on the axles/spindles will mostly affect only that corner. Fer instance, it pushes in left handers when you're on the gas, slide the right rear out just a bit to loosen that drive tire, or move the right front in by changing the shims on the spindle. If it gets to the point where it bicycles, loosen up that side. Changing tire compounds can be a real eye opener.
Tires are very track specific.. MG's at the one one normally go to (also what I inherited on the kart) and Le Conte at the track in McMinnville...