"What's your best Price?"

Those words absolutely aggravate me when I'm selling something. If I have a price on the item with no "OBO" designation, make me an offer. Don't ask what the "best price" is, because I'm going to tell you what I have listed. Anybody else have this issue(Duh)? How do you deal with it?

Anytime you deal in person with someone, whether you’re buying or selling, Some back-and-forth negotiation is to be expected. I’m usually amused by it. Many times it’s obvious whether the buyer you’re dealing with is serious or not, and what rubs me the wrong way is people that have no money, and no genuine interest in what you’re selling.
A few times when dealing with these kind of buyers and they asked me “what’s your best price?”
I’ve said “That depends. Are you talking about the best price for me, or the best price for you? “
That usually gets their attention, and sometimes they get upset, but I don’t care if they get angry since they’re just wasting my time anyway.