1 barrel blow through carb

That wouldn't be necessary, I don't believe. Just run a super six setup and it will probably run pretty good. I really don't think you'll have much luck with the one barrel. Hell try it. Stranger things have happened. Worst that can happen is you'll have a bunch of scrap metal layin in the street. It's not like you cannot find another slant six.
if i under drove the supercharger would there be a less possibility of it leaning out.