7875 + 5.9 + E85 + Megasquirt

Curious - I am converting my Gen III over to an MS3X and will be running Dakota Digital gauges - would the Pi allow me to make adjustments in TunerStudio on the fly while driving (Instead of having to use my laptop while driving)?
Yes, you definitely can. The Pi can run a full desktop with Tunerstudio installed on top. This little 7" screen I'm using is tiny and a bit difficult to navigate TS, but it can be done. I'm using a small bluetooth kbd/mouse combo.