7875 + 5.9 + E85 + Megasquirt

Yes, you definitely can. The Pi can run a full desktop with Tunerstudio installed on top. This little 7" screen I'm using is tiny and a bit difficult to navigate TS, but it can be done. I'm using a small bluetooth kbd/mouse combo.

Thanks for the response - I figure for minor tuning while out and about it would be easier to just leave the Pi in the glove box -- if major tuning needs to be done back at the garage with a laptop -- I appreciate the info