Looking at taking a road trip....

I’m looking at taking a road trip real soon, never been to Colorado, what’s it like there this time of year/early March? Anything really cool to see? How about Wyoming? I enjoy historic sites, museums, Americana, roads with awesome views. Or any other places in other states? I’m in Minnesota and have about a week of travel time for March, just wasn’t sure how the weather is out west with the snow and all, I’m sure many mountain areas will have more snow or passes closed. We love road trips and meeting new people so let me know what you got for ideas, thanks!
We went through Denver a few years ago in late January on our way to California. We encountered heavy snowfalls that caused road closures just before and just after we went through the area. The weather changes really fast around there. You should be prepared to wait out the weather if need be. Beautiful area with a lot of up and down driving. When the snow comes it can be fast and heavy. Kinda like the heavy spring snows we have in Minnesota except not as predictable.