Planning west coast Florida vacation. Suggestions? Comments?

Hi All. My nephew is getting married in Clearwater beach early May and we are spending 2 days there. After that we are looking for places to stay between Clearwater and Marco Island. Wife is very interested in Siesta Key but open to others (Marco, Sanibel, etc). I have never been to West coast Florida. She likes beach so has to be walking distance. I may do some fishing too. Looks like mostly Hotels and Condos. Prefer cottage/house/villa. We have 6 days and are using the usual VRBO, AirBNB and other interweb searches. Any ideas, suggestions good or bad?