I Need help 410 Stroker timing Carb Education

I have to assume that is a closed chamber head. I run 22 degress of base timing and 10 degrees mechanical. Total 32, my x headed 410 has always been very sensitive to total timing. 2 degrees either way and it falls off bad. Idles fine, even with a somewhat aggressive cam. These tend to like big carbs. I ran a mighty demon 825 wet flow on it back when it was 10:1 and it ran fine.