408 stroker 8-71 blower e85...teach me

Well I didn’t think you should be left hanging here so I’ll jump in with what I’ve learned. There are more than a few threads with valuable information in them here, but I’ll mention Subcom’s first build thread and Walker434’s thread since he’s also supercharged. Both threads are informative and have great participation from other members that will help catch you up on boosted small blocks. Other builds(off site) of significant note are Dizuster and Duner.
Dizuster has threads all over, but his posts on yellowbullet are especially informative. Duner has made big power as well, and more info can be found on DakotaRT and theturboforums. Both those builds are turbocharged, but they still highlight our engine weaknesses and strengths.

Back to your original question on compression. It’s my understanding that higher compression is mostly valuable to turbo cars to assist with off boost power and spool. Your roots build isn’t going to need help there. My personal preference is low compression for detonation resistance, and compensation via boost and timing. Regardless, a zero deck piston further improves detonation resistance. For pistons check out DSS pistons. They have stuff built for boost and, I believe, -29cc dishes for stroked sb mopar. Also consider Chevy 350 pistons which give you a .927 pin, shorter compression height, and a huge rod selection(speed master race I beams(6.2 and 6.25 lengths)) which can get you a more desirable rod/stroke ratio.

lastly: Tune Slow. Slower. Keep your timing stupid low under boost until you know your fuel curve is solid.