I’ve never seen where reverse cooling was enough to make a difference. If you drop the coolant temp it make an engine much less detonation prone.
And again, because it keeps getting said...aluminum heads will not allow for a higher CR, nor do they reduce detonation one iota.
Watch the engine masters episode where they test it. They had to abuse the engine to get the results everyone wants, and that is iron heads cause detonation. They do not.