Anything you can do to a TQ you can do to a Holley. And you can do more to the Holley. They are simple and this wouldn’t even be a question if Holley was so stupid and myopic. And if they didn’t put out piss poor tuning information.
I get a chuckle every time I read guys posting how Holley's are rich at idle and have poor drivability. It just proves that they never put in the effort to learn how to tune one. Just because you can run one straight out of the box doesn't mean you should.