Cruise Seems Lean

How deep into the throttle was your foot???

Enrichment is for heavy load relative to the engine's maximum capability at that rpm.
If the throttles were signifcantly over halfway open, then maybe yes.
Otherwise no.

Sorry Matt, maybe some confusion in this. I was just thinking about the carb design at this point and fuel flow/availability at part throttle being these are designed for WOT.

This is all relative to that long drive. With 2400 stall converter in 1971 Demon with 2.91 rear gears and 275 60 R15 tires. This was light throttle to maintain 2400-2500rpm cruise (~70mph). This was my concern originally, that maybe I wasn't in the main jet, and just out of idle mixture and/or transfer slots. It is a stack up issue? I didn't have an issue with the other gears and higher cruise rpm. Then the ambient outside temp/engine coolant temp as well.