Problem with Holley 4 bbl

This is a carb that was rebuilt.refurbished by a professional vendor. I was running this carb on this engine before I rebuilt it. It has a stock 1990 roller hydraulic cam and mixture adjustments worked. But it also had way more idle vacuum too.
I can get the mixture screws to affect the idle now as it should but almost no change in vacuum. I have them out about 3/4 turn. More in and it dies. I think I had the secondaries open too far before. We'll see how it runs when I get the chance to drive it.

That could have been it. See my comment above about how I adjusted mine.