Stroker Build... maybe

1; A sonic check will tell you how far you can go. I had 1 - 340 @.020 that was left with a cylinder wall thickness of .037 & less in thickness in some spots.

2; How much of the bottom of the cylinder that needs to be ground for clearance can depend on the connecting rod used.

The biggest stroke small block crank I have seen was a massive 4.25.