Pros & Cons of vacuum vs. mechanical secondaries?

I just installed a 750 dp onto my 408 and am impressed by the improved low and midrange response compared to the 750 VS I was running from BPE. Getting it "all in" when slamming the throttle open down low is amazing. Yes, fuel economy will be less, but I did not build my car for economy, but fun!
Exactly! Every time I see "MPG" in a post here about a hot rod I think "pussy!". lol Because in the end, if you tune properly for best performance, "whatever" your combination is will be getting its best mileage. People just cannot understand that.