At 400+hp, What kills A904s?

I run a 904 behind my 408 that's been mid 10s multiple times. 1.50 range 60 foot every time. Wheels up. Drive it on the street and it holds up just fine. All it really has done is it has the low 1st gear out of a slant 6 904 transmission, reverse manual valve body, 5 clutch hub with good clutches and a 5.0 lever.