EFI guys, any options for theft protection?

Maybe a bad tune that would crank but just barely run.
Back in the day (lol), some guys I knew pranking someone would switch 1 plug wire with the coil wire on the distributor cap. When the person came back and tried to crank their car, that one cylinder would fire making it sound like it wanted to crank but it never would.
How would it be in time to that one cylinder?