Since you indicate not much freeway travel over 50mph, I would lean toward the 3.91 gears.
Here is the formula for RPM
(MPH x gear ratio x 336) ÷ tire diameter in inches.
In this example with 3.91 gears at 50 mph with a 245 60R15 the result is
50 x 3.91 x 336 ÷ 26.6 = 2469 RPM.
Play around with the formula and variables to arrive at an RPM suitable to your driving style. In my experience 340's come alive with a little bit of gear.