100 shot of nitrous on 360 magnum engine

I'm a little curious as to what is meant by "constant timing adjustments."

Any modification that enhances the atmosphere going into an engine is likely to require timing adjustments, doesn't make it constant...you might have to make a few adjustments to dial it in, but once it's good and I don't mean running on a ragged edge good, i mean solid, repeatable, and safe-it's good until/unless you change something else in the combo, or am I missing the boat?