1967 Dart trunk area floor pan question

For small holes like that, that don’t appear super thin around the edges, i’ll wind a piece of tig filler rod close to the hole size, put a piece of copper behind it and zap with the mig. That is also how I like to fix vinyl top spots where the corner under the trim gets split. I bend to contour and buzz away
That idea works great on small holes. I have a weld spoon that's brass that I can stick behind small holes and just zap em shut. The ones he has on the sides are where the framerails are though. I don believe the OP has access to the backside there because the framerails are in the way.