Going to try for a new tow vehicle

UPDATE ON GAS MILEAGE:
Made a 90 mile trip this morning.
At 65 mph it runs right around 1500 RPM and gets about 20 MPG.
At 75 mph it runs at 1750 RPM and gets about 18.5 MPG.
The truck now has 250 miles on it, definitely not broken it yet, so these mileage figures are very encouraging!

Also, I had someone tell me to have the jake brake turned on even when I'm not towing. Your opinions on that.
Was this while towing? My 22 3500 Ram Diesel 4WD with 2500 miles got almost 24 empty going from Charlotte to Syracuse and back this past week with the cruise set at 66.