Cast to forged crank

Only hiccup of using the cast crank would be if you intend on using a standard transmission. There wouldn't be any factory provisions for a trans input shaft. If using an auto, then no worries.
That's a very valid point. Also, the cast cranks normally cannot be drilled to accommodate a manual transmission, without using the pilot bearing that presses into the crank register and cutting about 3/4" off of the transmission input shaft. If you try to drill them, you'll break into the crankshaft's oil galley. That would suck.