New bb build fuel economy

In australia in the early seventies a mate of ours was retiring and about to tow his caravan around Australia and had an almost new Ford Falcon panelvan with 250 cu ins six in it and it got about 12mpg towing and was slow. He wanted to build up his 1952 dodge truck up to tow with. We convinced him to buy all the parts out of a dodge car that was wrecking at the time and we had a low compression 440 engine to install. He put the 440 and torqueflite in it with 2.92 dodge diff , power steering etc. It was a weapon with power to spare and got 21mpg towing the caravan. He went all over Australia and it never missed a beat.
for sure when pulling a lot of weight bigger power just loafing along will be more economical than low power working it's nuts off. that's a given.