Planning a shop build, any suggestions?

Screws have basically no sheer strength. Nails have tremendous sheer strength.
Screws are not allowed for a large majority of items on a home. Just pick up the latest IBC code book, read it and ya might be surprised how often screws are not allowed. Pretty much, no hanger or connector should have screws used to fasten them. Roof sheeting should be staples as first choice, ring shank 8pn nails next. No screws should ever be used on sheeting. According to my code book and my engineer anyway. For that matter, most wood components should not be screwed together.

Bolts are different than screws. Bolts come with sheer values and are noted by the engineers as to what sizes to use for the sheer strength.

Screws are for trim and non structural construction.