Stroker 340>416 Build Advice

FWIW, I have closed chamber W2 iron heads, with Diamond dished pistons. My compression ratio is 10.12:1, I have no issues with detonation. You are in very safe territory with your suspected compression and aluminum heads, on pump gas. Depending on expected outcome, a set of ported Edelbrock heads work well on street engines. If it were me, I would look into the Trick Flow heads, if the budget allows. Do you intend to run a flat tapped solid, or roller cam? Either way the long arm of the stroker seems to favor narrower lobe separation angles like 106-108, also work well with your 4 speed. As previously stated, stroker engines generally use less total ignition timing, mine is all in at 32 degrees by 21-2200 rpm. Initial timing is 22 degrees. Stroker make so much torque, even with single plane intake you will like it on the street, although people have great success with RPM Air Gap.