Small block mileage

Everyone has their own ideal build, but mine would include a good lockup converter, 3.55 or so gears, and a 500/518 OD. Why not have your cake and eat it?
Because having your cake and eating it too would be not using worthless 3.55 gears with an OD. I'd consider 3.91s the absolute minumum. With 3.91s, your ratio in OD would be 2.69.