To Turbo or Supercharge

Draw-thru carb vs mpfi, the turbo body heats the inlet air even w/o boosting, draw-thru w/alky will help cool it. I have no idea what the OP is envisioning here, so just bringing some info to light. 400 hp isn't that lofty an output achievement, but durability as You say, is going to require a lot of attn.
Draw through should not even be considered at this point in the evolution of turbochargers and how awesome off the shelf blow through carburetors have become. Draw through stuff is ancient technology and gives you no ability to intercool at all. Durability aside (but also very important) 400 hp from a slant IS a lofty goal. There’s only a handful of people that have done it.