Any guys running low gear sets with strokers?

Just curious where the point is that a low gear set might make car ET better, as mine is fairly heavy and currently hooks anywhere.
Experiences , thoughts?
I have always run a 4.56 gear and a 29.0 inch tall slick. It has done 60' 1.42-1.44 footbraking with a 727 torqueflight. Don't know what the 1st gear ratio is. Years ago I tried a 32 inch tire and didn't see much if any difference in 60'. I think the key is to get the gear ratio to where it shifts down from the max hp range to where it is making max torque so you don't bog on the shift.