Fall drive from PA to Maryland? Why yes there are non- Interstate routes for that.

Yes... there are some great 2-lane routes along the mason-dixon. A fun drive is 220 South out of Bedford, PA. Roll it south as far as you want into WV and VA.
Thank you, I do need to Drive US 220 To VA / Roanoke Someday, From my place to US220 is only ~80 Miles so I will try it sometime.

I have Driven some sections of 220 in WV where it's concurrent with US 33 for a bit, but it was not much.

Thanks!
Greg