Fall drive from PA to Maryland? Why yes there are non- Interstate routes for that.

Thank you, I do need to Drive US 220 To VA / Roanoke Someday, From my place to US220 is only ~80 Miles so I will try it sometime.

I have Driven some sections of 220 in WV where it's concurrent with US 33 for a bit, but it was not much.

Thanks!
Greg

Another drive I've done up your way is Route 31... West Newton to Bedford