Beefing up A500 overdrive

How much power? You can upgrade the OD section of an 42 or 44 to 46, 47 or 48 OD internals. But, the OD on an RE/RH transmission costs a lot of power, and increasing pinion and clutch count requires careful consideration based on what you're trying to accomplish.

The front portion of that transmission you're stuck with the smaller input assembly and intermediate shaft, which will be your weak link with more power or forced induction.
when you say "costs a lot of power" how much are the losses on a 500/42 RH?

I'm looking to go this route with a 375hp LA that will either see injection or swap to a G3 down the line. what would be the best course of action- building out an OD unit or go with a gear vendors unit?

currently has a 727 and I'm not racing it