Big carb (Quick Fuel 850) on a small engine?

As with everything else, it's all in the tune. I'm getting ready to swap a 650 double pumper on my slant 6. It had a 450 vacuum secondary carburetor on it now. I'm not the least bit concerned that I cannot get it tuned with all the modern tuning it has built into it. Might take a little time to get it dialed in, but it'll get there.