Holley 4791 Carburetor

No work beyond the ordinary carb setup routine such as idle speed, idle mixture, etc. Being a vacuum secondary setup, it's pretty simple and straightforward. Follow the procedures in the factory service manual which can be found online if you don't own one. The only setting I think that might require a bit of extra work is idle mixture screw setting. I'm assuming--possibly incorrectly--that there might be some minor differences in that setting based on manual-transmission idle (trans in neutral) v. auto trans idle (idling in gear) based on load. If you really want to get tweaky, you could find all the air bleed/fuel restriction orifice measurements (in a carb manual) and modify the carb to manual specification, but I really believe that would be effort wasted. The secondary vacuum-diaphragm springs might want a little adjustment, but those are easily changed on the car and best tested by driving. Trust your butt dyno.

Put it on and run it. Tweak as necessary. It's no different than any other carb change, other than the jetting/air bleeds/fuel restrictions will be way closer to perfect right off the hop.