LA blocks

Sure they can, I've seen a handful of 318s with a 4" bore. But just because you can doesn't mean you should - always go with the smallest overbore you can get away with so it doesnt flex. Plus they aren't making these things any more and you might get another rebuild out of it.
My 318 is 0.060" over, thinnest cylinder is 0.167" on the trust side.
For clarity 4.00" in a 318 is .090" over? and you've seen this? I personally would go over just enough to clean it up .010" at a time. But I am conservative and would want to get another rebuild also.