Degreeing a Cam Shaft

The angle is irrelevant if you are using the same reading on the dial indicator for opening and closing. If one reads 2 open and 40 close with it perfectly in line and the off angle one reads 1 and 39... it's still a 109CL

The math doesn't care.
If the dial indicator is grossly off, yes you will get the same centerline but your duration at 0.050" will be less then what is on the cam card. The max lift will also be reduced and then you question the grind of the camshaft.