“Max effort daily driver” 318 build vs “Budget” 400 swap

Funny that you mention a 218 @ 0.050 cam for the 318, since the camshaft I'd use If I were to build the small block would be a comp cams 268H.......

I actually started out by picking the 3.21 gears. My car has 26 inch tall tires. Cruise RPMS at 65mph calc out to 2700, and 2300 at 55mph. Going to 3.55 gears would have put my my 65mph rpms at 3000. I know some guys have no problems cruising at 3k rpms, but I would rather cruise below that. Like you said, settling for 3.21 gears puts a limit in my camshaft selection. Although I would still choose the same cam even if I had an overdrive trans and 4.10 gears.

Next thing I did was calc out the compression ratio. Using KB flat tops 0.012" down the hole, 0.028" thick gaskets and eddy heads with 63cc chambers calcs out to 9.5. Milling the heads to 60cc brings it up to 9.9. With a compression ratio in this range, I picked out he comp 268H for 2 reasons. First, in this thread they dynoed a 9.1:1 318 with eddy heads and 252h camshaft. A build like that is my idea of a "max effort daily driver". Cranking pressure on that engine was measured at 170psi, and dynamic compression calcs out at 7.88:1 using the wallace calculator. I would have no problem using a camshaft that size, since it worked so good in that build. But using that camshaft on a 9.5:1 engine results in a 8.22:1 dcr. I feel that's a bit too high. The 268 with the same static compression ratio spits out a 7.81:1 dynamic comp ratio. Second reason I chose this cam is because I expect it to work with my factory converter. Someone with way more experience can chime in on this, but I understand this cam will come on somewhere between 1500 and 2000 rpms. And regarding David Vizard's 128 rule, a 110 LSA is what it calls for in this application (318 with 2.02 valves and between 9.5-10.5 comp).
iam running that combo now
68 340 thin head gasket 268 H 218@50 454 lift 110/106 manifolds free flowing exhaust elec ign stealth 650 dp tuned carb power timed 727 tf2 3.23s now 3.91s 235 60 14s
169 cranking psi
10-1 comp
8.21 dyn comp
vp index 138
its a great street cam smallest ive used lots of low end pulls hard to 5700 5800
100k plus bottom end virgin from 1968 fresh top end
with 3.91s id use the 270 H or the xe268 221 228 cam
with the 3.23s dead stop punch tach goes to 5700 spins 45 50 feet 10 feet in 2nd
with 3.91s right to 5700 45 feet shift to second tach stays @5700 for another 45 50 feet if i so choose
edit
your combo 3.21 gears id use comp cam ex256h 212/218 447/454 110
would be about equal to my 340 218@50 3.23s