Best Gears for a 408 Stroker?

Less gear, less snap. No way around it. 408's like to windup, so you will lose some grunt, but you and the engine will be happier. I had a 408 with 3:73's and a 4-speed and I liked it but, the highway was a problem. 3:23's will help but... .. "IMHO" without knowing your setup, a well tuned 750 should do you for your street car .. subject to disapproval of course :) :)