Alignment with ductile-iron rockers?

Not really sure what you are asking but if you are asking if the rocker should be centered over the valve the answer is yes. Back in my stock hold-down days I’ve had to grind the tabs off the stock hold downs so I could shim the rockers over. I spend a lot of time doing this job once then it’s done for the life of the set up.
Good edit. Yes, by lateral alignment I did mean centered side to side over the valve. For the previous setup I used stock hold-downs and also ground the tabs off. Still looked jury-rigged but didn't show any unusual wear after 1300 street miles.

It looks like I can take .080 off each side of the aluminum hold-downs and that will put the rocker pad squarely over the valve tip. Time to break out the belt sander ;)